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1: Clin Calcium. 2004 Jun;14(6):116-22.Links

[Sevelamer hydrochloride prevents ectopic calcification of blood vessels]

[Article in Japanese]

Fukushima N, Nagano N.

Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.

Sevelamer hydrochloride is a non-absorbed calcium- and metal-free phosphate binder that lowers the serum phosphorus levels in hemodialysis patients. Sevelamer contains multiple amines, which are partially protonated and interact with phosphate molecules through ionic and hydrogen bonding. We show the in vitro phosphate binding assay data and the efficacy of sevelamer to lower the serum phosphorus and calcium phosphorus product in several animal models. Furthermore, we indicate the vivid data that sevelamer prevented the ectopic calcification of aorta in adenine induced renal failure model, which represent severe hyperphosphatemia and the related dialysis complications.

PMID: 15577065 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Sevelamer (Renagel® )

    Sevelamer is used to treat high blood levels of phosphorous in patients with kidney disease who are on dialysis. It binds phosphorous that you get from foods in your diet and prevents it from being absorbed into your blo...

  • Source: AHFS Consumer Medication Information