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Clin Calcium. 2004 Jun;14(6):16-22.

[Control of calcification by extracellular matrix].

[Article in Japanese]

Author information

  • 1Department of MENICON cartilage and Bone Regeneration, Graduate School of Medicine, The University of Tokyo.


Physiological calcification begins from crystallization of hydroxyapatite in extracellular matrix of both bones and teeth. Because calcification is exactly the extracellular event, organic components of extracellular matrix play important roles in control of calcification. The authors discuss the molecular regulation of calcification by organic components of extracellular matrix, focusing on the mineral/organic interaction.

[PubMed - indexed for MEDLINE]
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