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    J Bacteriol. 2004 Dec;186(24):8317-25.

    Negative regulation of DNA repair gene (ung) expression by the CpxR/CpxA two-component system in Escherichia coli K-12 and induction of mutations by increased expression of CpxR.

    Ogasawara H, Teramoto J, Hirao K, Yamamoto K, Ishihama A, Utsumi R.

    Source

    Department of Bioscience and Biotechnology, Graduate School of Agriculture of Kinki University, 3327-204 Nakamachi, Nara 631-8505, Japan.

    Abstract

    In Escherichia coli K-12 overexpressing CpxR, transcription of the ung gene for uracil-DNA glycosylase was repressed, ultimately leading to the induction of mutation. Gel shift, DNase I footprinting, and in vitro transcription assays all indicated negative regulation of ung transcription by phosphorylated CpxR. Based on the accumulated results, we conclude that ung gene expression is negatively regulated by the two-component system of CpxR/CpxA signal transduction.

    PMID:
    15576781
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC532440
    Free PMC Article

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