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Genome Biol. 2004;5(12):R101. Epub 2004 Nov 26.

GOToolBox: functional analysis of gene datasets based on Gene Ontology.

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  • 1Laboratoire de Génétique et Physiologie du Développement, IBDM, CNRS/INSERM/Université de la Méditerranée, Parc Scientifique de Luminy, case 907, 13288 Marseille, France. martin@ibdm.univ-mrs.fr

Abstract

We have developed methods and tools based on the Gene Ontology (GO) resource allowing the identification of statistically over- or under-represented terms in a gene dataset; the clustering of functionally related genes within a set; and the retrieval of genes sharing annotations with a query gene. GO annotations can also be constrained to a slim hierarchy or a given level of the ontology. The source codes are available upon request, and distributed under the GPL license.

PMID:
15575967
[PubMed - indexed for MEDLINE]
PMCID:
PMC545796
Free PMC Article
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