J Mol Evol. 1992 Jan;34(1):3-16.

Inching toward reality: an improved likelihood model of sequence evolution.

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Department of Genetics SK-50, University of Washington, Seattle 98195.

Abstract

Our previous evolutionary model is generalized to permit approximate treatment of multiple-base insertions and deletions as well as regional heterogeneity of substitution rates. Parameter estimation and alignment procedures that incorporate these generalizations are developed. Simulations are used to assess the accuracy of the parameter estimation procedure and an example of an inferred alignment is included.

PMID:: 1556741; [PubMed - indexed for MEDLINE]

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5R01 GM41716/GM/NIGMS NIH HHS/United States

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