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J Clin Virol. 2004 Dec;31 Suppl 1:S3-6.

Prevalence of HCV coinfection in HIV-infected individuals in Nigeria and characterization of HCV genotypes.

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  • 1Gede AIDS and Infectious Diseases Research Institute, 9 Zaire Crescent, Maitama, PMB 5158 Wuse, Abuja, Nigeria.

Abstract

BACKGROUND:

Coinfection with hepatitis C virus (HCV) in individuals infected with HIV is associated with a higher incidence of liver injury, hepatic decompensation, and decreased survival time than that seen in an HIV-monoinfected population. While prevalence studies on HIV/HCV coinfection have been performed in the U.S. and in some European countries, little is known about coinfection rates in Africa.

DESIGN:

Retrospectively collected specimens from 146 confirmed HIV-positive individuals in Nigeria who had access to antiretroviral therapy (ART) were tested for HCV RNA, using the VERSANT HCV RNA qualitative assay (TMA), and, if HCV RNA-positive, for HCV genotype using the VERSANT HCV genotype assay (LiPA).

RESULTS:

Twelve out of the 146 individuals tested (8.2%) were HCV positive. Nine of the 12 HCV-positive individuals were infected with HCV genotype 1 (five 1a, three 1b, one non-subtypable) and three were infected with HCV genotype 2 (all non-subtypable). Coinfected individuals were more likely to be male, older, and have lower CD4+ cell counts than HIV-monoinfected individuals, although none of the differences reached statistical significance.

CONCLUSION:

The results highlight the potential public health impact of HCV infection in Nigeria, where anti-HCV testing is generally not performed in HIV-infected populations or in most blood transfusion centers.

PMID:
15567088
[PubMed - indexed for MEDLINE]
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