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Nat Prod Rep. 2004 Dec;21(6):722-30. Epub 2004 Oct 20.

Chemical aspects of amine oxidation by flavoprotein enzymes.

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  • 1Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK.

Erratum in

  • Nat Prod Rep. 2005 Apr;22(2):306.


The mechanism of amine oxidation by flavoprotein enzymes is critically analysed through analysis of available experimental data. The review assesses available evidence for radical and polar mechanisms, drawing on data from model reactions, kinetic and spectroscopic approaches, structural and mutagenesis studies. The review focused on studies of mammalian monoamine oxidases and the bacterial enzymes trimethylamine dehydrogenase, monomeric sarcosine oxidase and dimethylglycine oxidase.

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