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J Am Chem Soc. 2004 Dec 1;126(47):15368-9.

Protein patterning based on electrochemical activation of bioinactive surfaces with hydroquinone-caged biotin.

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  • 1Korea Research Institute of Standards and Science, Daejeon 305-600, Korea.


We report a protein attachment and patterning method based on a hydroquinone-caged biotin surface that generates bioactive biotin by mild electrochemical perturbation. The electrochemical activation proceeds under the buffered aqueous environment at neutral pH. It also allows site-selective generation of bioactive biotin for the immobilization of target protein by using prepatterned electrode arrays.

[PubMed - indexed for MEDLINE]
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