Format

Send to

Choose Destination
See comment in PubMed Commons below
Evolution. 2004 Oct;58(10):2377-81.

Genetic correlation between melanization and antibacterial immune responses in a natural population of the malaria vector Anopheles gambiae.

Author information

  • 1Laboratoire de Parasitologie Evolutive, CNRS UMR 7103, Universit√© Pierre and Marie Curie, CC237, 7 quai St Bernard, 75252 Paris Cedex 05, France. Louis.Lambrechts@snv.jussieu.fr

Abstract

The immune system of invertebrates can mount different responses, including melanotic encapsulation and several antibacterial defense mechanisms. Variation of the efficacies of these responses is generally considered to be a product of the evolutionary pressure on each response due to infection by parasites. However, potential interactions and trade-offs among the different responses of the immune system could constrain the evolutionary potential of each response. In a natural population of the mosquito Anopheles gambiae, we measured the genetic association between the melanization response and an antibacterial response in two environmental qualities (well-fed and undernourished larvae). In both environments the two immune responses were positively genetically correlated: in full-sib families that were most likely to melanize a bead, injected bacteria were most likely to be cleared. Thus, our data do not support the idea of a trade-off among different outcomes of the invertebrate immune system, but rather that some families are overall immunologically superior to others.

PMID:
15562698
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk