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    Diabetes. 2004 Dec;53(12):3323-7.

    Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice.

    Deruytter N, Boulard O, Garchon HJ.

    INSERM U580, Université Paris V-René Descartes, Paris, France.

    Major histocompatibility complex (MHC) plays a largely predominant role in the genetic predisposition to type 1 diabetes, in both humans and rodents. While class II loci have long been recognized as essential, they do not fully explain the MHC-linked genetic component of type 1 diabetes. In the present study, using new NOD congenic strains harboring defined chromosomal segments from C57BL/6 mice, we circumscribed three distinct loci influencing murine type 1 diabetes and tightly linked to but separated from the class II region. Our findings might guide the search for additional HLA-linked loci in human type 1 diabetes.

    PMID: 15561967 [PubMed - indexed for MEDLINE]

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