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1: Phytochemistry. 2004 Dec;65(24):3255-9.Click here to read Links

Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase.

Ovenden SP, Yu J, Wan SS, Sberna G, Tait RM, Rhodes D, Cox S, Coates J, Walsh NG, Meurer-Grimes BM.

Cerylid Biosciences Ltd., 576 Swan Street, Richmond, Vic. 3121, Australia.

An HTS campaign aimed at the identification of inhibitors of HIV integrase showed that the methanol extract from the buds of a Eucalyptus globoidea was active. Bioassay guided fractionation of this extract resulted in the purification and structural elucidation of the lignan, globoidnan A (1) as the only compound in the extract responsible for the inhibition of HIV integrase. The compound was found to inhibit the combined 3' processing and strand transfer activity of HIV integrase with an IC50=0.64 microM.

PMID: 15561191 [PubMed - indexed for MEDLINE]