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1: J Enzyme Inhib Med Chem. 2004 Aug;19(4):367-71.Links

Synthesis and urease enzyme inhibitory effects of some dicoumarols.

Khan KM, Iqbal S, Lodhi MA, Maharvi GM, Perveen S, Choudhary MI, Atta-Ur-Rahman, Chohan ZH, Supuran CT.

H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan. hassaan2@super.net.pk

Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 microM.

PMID: 15558955 [PubMed - indexed for MEDLINE]