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1: South Med J. 2004 Oct;97(10):948-50. Links

Erythema marginatum and hereditary angioedema.

Starr JC, Brasher GW, Rao A, Posey D.

Division of Allergy & Immunology, Department of Pathology, Scott & White, Scott, Sherwood, TX, USA. jstarr@swmail.sw.org

OBJECTIVE: To search for anaphylatoxin activity in plasma during episodes of erythema marginatum, and to evaluate the histology of erythema marginatum by electron microscopy and immunohistologic techniques. METHODS: Plasma samples were studied for C5a activity by granulocyte aggregation, and C3 conversion by immunoelectrophoresis. A skin biopsy of erythema marginatum was done, and the tissue stained with a rabbit antibody to bradykinin. RESULTS: No plasma anaphylatoxin was found. Dense deposits of bradykinin were discovered in stromal tissue and lining endothelial cells. CONCLUSIONS: Bradykinin may be important in the causality of the erythema marginatum associated with hereditary angioedema.

PMID: 15558919 [PubMed - indexed for MEDLINE]