Neurology. 2004 Nov 23;63(10):1944-6.

Late-onset optic pathway tumors in children with neurofibromatosis 1.

Listernick R, Ferner RE, Piersall L, Sharif S, Gutmann DH, Charrow J.

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Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. boblist@northwestern.edu

Abstract

Identification of new optic pathway tumors (OPTs) and progression of pre-existing OPTs in children with neurofibromatosis 1 (NF1) have been reported infrequently after age 6. The authors present eight children with NF1 (mean age 12.2 years) seen in three NF1 centers who had either late-onset (four of eight) or late-progressive (seven of eight) OPT. Continued monitoring of individuals with NF1 into adulthood for the development of OPTs and for progression of known OPTs is warranted.

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