[The role of the leukocytes in increasing the vascular permeability in an infectious inflammation focus]

The model of acute infectious peritonitis in rats with vinblastine-induced leukopenia has been used to show that the leukocyte depletion significantly influences the vascular permeability of abdominal cavity during the whole period of exudation. It inhibits the vascular permeability rise both in the immediate phase and in the initial period of delayed phase (5 h). 12 hours-5 days after the inflammatory agent action the vascular permeability under conditions of primary leukopenia appears to be more than in the natural course of inflammation, that coincides with excess of the leukocyte number usual for the inflammatory focus and with its significant increase in blood. The results indicate the essential role of leukocytes both during the immediate and delayed phases of increase in the vascular permeability of inflammatory infectious focus.

PMID: 1555730 [PubMed - indexed for MEDLINE]