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Curr Biol. 2004 Nov 23;14(22):R968-70.

Membrane traffic: controlling membrane fusion by modifying NSF.

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  • 1The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown St., P.O. Box 147, Liverpool L69 3BX, UK.


Recent studies show that NSF, isolated over 15 years ago as a protein required for membrane fusion in vitro, can be reversibly inactivated by both S-nitrosylation and tyrosine phosphorylation. Different cell types use distinct post-translational modifications of NSF for localized regulation of membrane fusion.

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