Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Microbiol. 2004 Dec;7(6):579-86.

Sporulation of Bacillus subtilis.

Author information

  • 1Department of Microbiology and Immunology, Temple University School of Medicine. 3400N. Broad St., Philadelphia, Pennsylvania 19140, USA.


Differentiation of vegetative Bacillus subtilis into heat resistant spores is initiated by the activation of the key transcription regulator Spo0A through the phosphorelay. Subsequent events depend on the cell compartment-specific action of a series of RNA polymerase sigma factors. Analysis of genes in the Spo0A regulon has helped delineate the mechanisms of axial chromatin formation and asymmetric division. There have been considerable advances in our understanding of critical controls that act to regulate the phosphorelay and to activate the sigma factors.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk