Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Clin Psychiatry. 2004;65 Suppl 14:18-21.

Serotonin-1D hypothesis of obsessive-compulsive disorder: an update.

Author information

  • 1Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Tel Aviv University, Israel. jzohar@post.tau.ac.il

Abstract

Support for the serotonin-1D (5-HT(1D)) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT(1D) agonist sumatriptan, and case reports in which prolonged administration of 5-HT(1D) agonists was associated with a therapeutic effect, suggest that 5-HT(1D) may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT(1D) gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT(1D) hypothesis requires further investigation in order to disentangle the role of the 5-HT(1D) receptor in this common and often severe disorder.

PMID:
15554784
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Dartmouth Journal Services
    Loading ...
    Write to the Help Desk