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Nat Rev Neurosci. 2004 Dec;5(12):917-30.

Stress, cognitive impairment and cell adhesion molecules.

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  • 1Laboratory of Behavioral Genetics, Brain Mind Institute, Swiss Federal Institute of Technology, EPFL, CH-1015 Lausanne, Switzerland. carmen.sandi@epfl.ch

Abstract

Stress has profound effects on brain structure and function, but the underlying mechanisms are still poorly understood. Recent studies imply that neuronal cell adhesion molecules of the immunoglobulin superfamily--NCAM and L1--are important mediators of the effects of stress on the brain. Chronic stress regimes that lead to hippocampal atrophy and spatial-learning impairment in rodents simultaneously induce a pattern of changes in cell adhesion molecule expression that fits with a role for these molecules in stress-induced neuronal damage and neuroprotective mechanisms. These findings highlight cell adhesion molecules as potential therapeutic targets to treat stress-related cognitive disturbances.

PMID:
15550947
[PubMed - indexed for MEDLINE]
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