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Physiology (Bethesda). 2004 Dec;19:355-61.

ARC channels: a novel pathway for receptor-activated calcium entry.

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  • 1Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA. trevor_shuttleworth@urmc.rochester.edu


In many nonexcitable cells, stimulation with low agonist concentrations specifically activates Ca2+ entry via arachidonic acid-regulated, highly Ca2+-selective ARC channels. Only at high agonist concentrations are the more widely studied store-operated channels activated, producing sustained elevated cytosolic Ca2+ concentration signals. These signals activate calcineurin, which in turn inhibits the ARC channels, resulting in a "reciprocal regulation" of these two distinct Ca2+-entry pathways that may have important functional implications for the cell.

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