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Bioorg Med Chem Lett. 2004 Dec 20;14(24):6045-8.

Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies.

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  • 1Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.


We have developed an efficient and selective radioligand, the [35S]-radiolabeled dihydroquinoxalinone derivative, 4, for an ex vivo receptor occupancy assay in transgenic rats over-expressing the human bradykinin B1 receptor.

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