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Bioorg Med Chem Lett. 2004 Dec 20;14(24):5979-81.

Multidrug resistance reversal activity of permethyl ningalin B amide derivatives.

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  • 1Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.


A series of amide derivatives of permethyl ningalin B were prepared and examined as multidrug resistance (MDR) reversal agents illustrating that the C5 carboxylate is widely tolerant of such derivatization.

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