Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2004 Nov 11;1694(1-3):149-61.

Type I secretion in gram-negative bacteria.

Author information

  • 1Unité des Membranes Bactériennes, Département de Microbiologie fondamentale et médicale, Institut Pasteur, 25-28, rue du Dr. Roux, 75724 Paris, Cedex 15, France. pdelep@pasteur.fr <pdelep@pasteur.fr>

Abstract

In gram-negative bacteria, type I secretion is carried out by a translocator made up of three proteins that span the cell envelope. One of these proteins is a specific outer membrane protein (OMP) and the other two are cytoplasmic membrane proteins: an ATP-binding cassette (ABC) and the so-called membrane fusion or adaptor protein (MFP). Type I secretion is sec-independent and bypasses the periplasm. This widespread pathway allows the secretion of proteins of diverse sizes and functions via a C-terminal uncleaved secretion signal. This C-terminal secretion signal specifically recognizes the ABC protein, triggering the assembly of the functional trans-envelope complex. This report will mainly deal will recent data concerning the structure and assembly of the secretion complex as well as the effects and role of substrate folding on secretion by this pathway.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk