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J Clin Invest. 2004 Nov;114(10):1412-4.

What determines glomerular capillary permeability?

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  • 1Department of Chemical Engineering, Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.


There have been exciting recent advances in our understanding of the structural and molecular biology of the glomerular slit diaphragm, as described in a report in this issue of the JCI. These findings, combined with data on the permeability of the basement membrane and evidence that the endothelium may be a more important barrier than often supposed, are allowing a clearer understanding to emerge of how the 3 parts of the glomerular capillary wall jointly determine its functional properties.

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