Format

Send to

Choose Destination
See comment in PubMed Commons below
Br Heart J. 1992 Mar;67(3):236-9.

Aortic and mitral valve disease in patients with end stage renal failure on long-term haemodialysis.

Author information

  • 1Department of Medicine, Kantonsspital Aarau, Switzerland.

Abstract

OBJECTIVE:

To identify valvar heart disease in patients with chronic uraemia by conventional and colour coded Doppler echocardiography.

DESIGN:

Case series of an unselected group of 62 patients with end stage renal failure.

SETTING:

Centre for haemodialysis in a referral hospital in Switzerland.

PATIENTS:

62 patients on chronic haemodialysis.

MAIN OUTCOME MEASURES:

Frequency of structural and functional valve abnormalities and their relation to clinical findings.

RESULTS:

Structural changes were seen in 40 (64%) of 62 patients after 50 months (range 3-178 months) on haemodialysis. The mitral annulus and aortic cusps were thickened in 25 (40%) and in 34 (55%) patients respectively. Aortic stenosis was present in eight (mean (SD) age 60.5 (8.5) years), with a maximal instantaneous pressure gradient of 41 (14) mm Hg. Aortic regurgitation was seen in eight, mitral regurgitation in seven, and mitral stenosis in three patients. Patients with aortic stenosis had been on haemodialysis for significantly longer than the remaining patients (101 (43) v 46 (43) months, p = 0.01) and had significantly higher concentrations of serum alkaline phosphatase (176 (89) v 117 (47) IU/l, p less than 0.01) and of parathyroid hormone (54 (66) v 19 (29) ng/ml, p less than 0.02).

CONCLUSIONS:

Patients on long-term haemodialysis had an increased frequency of haemodynamically relevant changes in the aortic and mitral valves. The degenerative valve disease may be related in part to the duration of haemodialysis and to alterations in calcium metabolism as indicated by increased plasma concentrations of alkaline phosphatase and parathyroid hormone.

PMID:
1554541
PMCID:
PMC1024798
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk