Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mech Ageing Dev. 2004 Oct-Nov;125(10-11):707-17.

Convergence of lipid homeostasis through liver X and thyroid hormone receptors.

Author information

  • 1Karo Bio AB, Novum 141 57 Huddinge, Sweden. anders.berkenstam@karobio.se

Abstract

Members of the nuclear receptor gene family act as biological rheostats to maintain metabolic homeostasis in response to endocrine and nutritional changes. The liver X (LXR) and thyroid hormone (TR) receptors have been shown to regulate overlapping but distinct metabolic pathways important for overall lipid homeostasis. Dyslipidemia is one out of four key determinants for cardiovascular risk and both LXRs and TRs may provide attractive targets for intervention of cardiovascular disease. In this review we will compare the two receptor systems to highlight similarities and differences in structure and function with implications for development of novel treatments for dyslipidemia and atherosclerosis.

PMID:
15541766
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk