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    Biochem Biophys Res Commun. 2004 Dec 17;325(3):649-52.

    The problem of protein kinase activity of small heat shock protein Hsp22 (H11 or HspB8).

    Kim MV, Seit-Nebi AS, Gusev NB.

    Source

    Department of Biochemistry, School of Biology, Moscow State University, Moscow 119992, Russia.

    Abstract

    The recently described protein denoted H11, Hsp22 or HspB8 seems to participate in regulation of proliferation, apoptosis, and cardiac hypertrophy. Mutation of Hsp22 causes distal motor neuropathy. Multitude action of Hsp22 is supposed to be due to its protein kinase and/or chaperone-like activities. There are many indirect evidences indicating that Hsp22 possesses intrinsic protein kinase activity. However, low homology to protein kinases, low extent of autophosphorylation, lack of significant protein kinase activity with commonly used substrates, and lack of information on stoichiometry, kinetics, and substrate specificity make the existence of intrinsic protein kinase activity of Hsp22 questionable. It is supposed that protein kinase activity ascribed to Hsp22 is due to contaminating protein kinases. Hsp22 is highly homologous to small heat shock proteins and effectively prevents aggregation of denatured protein both in vitro and in vivo. Therefore, it is supposed that chaperone-like activity is of great importance for Hsp22 functioning.

    PMID:
    15541337
    [PubMed - indexed for MEDLINE]

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