Br J Dermatol. 2004 Nov;151(5):1090-2.

Leukocytapheresis treatment for pyoderma gangrenosum.

Fujimoto E, Fujimoto N, Kuroda K, Tajima S.

Source

Department of Dermatology, National Defence Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. srg1936@gr.ndmc.ac.jp

Abstract

A 42-year-old man presented with painful erythema with pustules and multiple small ulcers on the shins. He had suffered from ulcerative colitis (UC) and received oral glucocorticosteroid and salicylazosulfapyridine therapies for 7 years. Biopsy of the lesion demonstrated mixed cellular infiltrates with dominant neutrophils. The patient was diagnosed with pyoderma gangrenosum (PG) and underwent leukocytapheresis (LCAP), an extracorporeal leucocyte removal therapy, once a week for 5 weeks without changing the doses of the oral medications. The skin lesions as well as clinical signs of UC rapidly improved after LCAP, and no recurrence was seen during a follow-up period. There were no major complications during LCAP. LCAP will provide an effective and safe tool for the treatment of PG.

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