Ligand discovery using small molecule microarrays. [J Pharmacol Exp Ther. 2005]

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1: J Pharmacol Exp Ther. 2005 Apr;313(1):1-7. Epub 2004 Nov 10. Links

Ligand discovery using small molecule microarrays.

He XG, Gerona-Navarro G, Jaffrey SR.

Department of Pharmacology, Weill Medical College, Cornell University, 1300 York Avenue, Box 70, New York, NY 10021, USA.

Small molecule microarrays have recently been used to identify ligands for several proteins, and several themes regarding screening strategies and limitations have emerged. In this review, some of the technical issues related to the manufacture and screening of small molecule microarrays, as well as prospects for small molecule microarrays in several areas of drug discovery and chemistry, are discussed.

PMID: 15537823 [PubMed - indexed for MEDLINE]

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Ligand discovery using small molecule microarrays.

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