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Int Semin Surg Oncol. 2004 Nov 10;1(1):11.

Anti-Ri antibodies associated with short-term memory deficits and a mature cystic teratoma of the ovary.

Author information

  • 1Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. oluwole.fadare@yale.edu.

Abstract

BACKGROUND:

The IgG autoantibody ANNA-2 (anti-Ri) is a type 2 antineuronal antibody that has been found to bind to highly conserved and widely distributed adult brain proteins encoded by the Nova-1 and Nova-2 genes. Anti-Ri antibodies are typically detected in the serum and cerebrospinal fluids of patients with neurological disorders such as opsoclonus/myoclonus and cerebellar ataxia and in association with gynecologic and breast malignancies.

CASE PRESENTATION:

This report describes an unusual example of a 33-year-old female patient who developed short-term memory deficits over a 3-month period. An extensive neurological work-up, including a panel of paraneoplastic markers was negative with the exception of a high titer serum Anti-Ri (1:15,3600). A large left ovarian mass was palpated, surgically resected and eventually diagnosed as a mature cystic teratoma. Post-operatively, memory deficits had disappeared within 1 month and serum Anti-Ri titers had decreased significantly to 1:256. An extensive diagnostic work-up for other malignancies was negative.

CONCLUSION:

Although, Anti-Ri antibodies are typically associated with malignancies, this case illustrates the potential association between benign tumors and this autoantibody.

PMID:
15537431
[PubMed - as supplied by publisher]
PMCID:
PMC534089
Free PMC Article
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