Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-...[J Med Chem. 2004]

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1: J Med Chem. 2004 Nov 18;47(24):6100-3. Links

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Sidwell RW, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA.

Pharmasset Inc., Tucker, Georgia 30084, Utah State University, Logan, Utah 84322, USA. pwang@pharmasset.com

A novel anti-hepatitis C virus (HCV) agent, N(3),5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine.

PMID: 15537363 [PubMed - indexed for MEDLINE]

Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives. [J Med Chem. 2005]
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents. [Nucleosides Nucleotides Nucleic Acids. 2005]
Nucleoside analog inhibitors of hepatitis C virus replication. [Infect Disord Drug Targets. 2006]
Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents. [Nucleosides Nucleotides Nucleic Acids. 2007]
Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors. [Antimicrob Agents Chemother. 2008]
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Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

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