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    J Med Chem. 2004 Nov 18;47(24):6100-3.

    Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

    Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Sidwell RW, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA.

    Pharmasset Inc., Tucker, Georgia 30084, Utah State University, Logan, Utah 84322, USA. pwang@pharmasset.com

    A novel anti-hepatitis C virus (HCV) agent, N(3),5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine.

    PMID: 15537363 [PubMed - indexed for MEDLINE]

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