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Cogn Behav Neurol. 2004 Sep;17(3):133-8.

Alterations of the sense of "humanness" in right hemisphere predominant frontotemporal dementia patients.

Author information

  • 1David Geffen School of Medicine at UCLA, The University of California at Los Angeles, Los Angeles, California, USA. Mmendez@UCLA.edu

Abstract

OBJECTIVE:

To evaluate the sense of "humanness" in frontotemporal dementia (FTD) patients with right hemispheric involvement.

BACKGROUND:

Early in the course, FTD is often asymmetric, and those with predominant right frontotemporal disease have disproportionate disturbances in social behavior and empathy. A disruption in a sense of humanness may underlie these behavioral disturbances.

METHOD:

Sixteen patients with asymmetric FTD on functional neuroimaging underwent recognition tests of facial masking, human-animal morphing, and facial distortion. Additional tests evaluated facial discrimination and the recognition of famous faces, facial emotions, and animate-inanimate differences.

RESULTS:

On the distorted and morphed face tasks, 8 FTD patients with predominant right hemisphere involvement were significantly more likely to call morphed and distorted faces "human" as compared with both 8 FTD patients with predominant left hemisphere involvement and normal controls. The FTD groups did not differ on thresholds for recognizing masked faces or on other face recognition measures.

CONCLUSIONS:

In FTD, right hemispheric involvement may alter the threshold for judging someone as human independent of the recognition of faces or facial affect. These results suggest that a specific sense of humanness facilitates a person recognition network in the right frontotemporal region of the brain.

PMID:
15536300
[PubMed - indexed for MEDLINE]
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