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Genome Biol. 2004;5(11):R92. Epub 2004 Oct 25.

Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana.

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  • 1Reverse Engineering Group, Swiss Federal Institute of Technology (ETH), Zurich. awille@inf.ethz.ch


We present a novel graphical Gaussian modeling approach for reverse engineering of genetic regulatory networks with many genes and few observations. When applying our approach to infer a gene network for isoprenoid biosynthesis in Arabidopsis thaliana, we detect modules of closely connected genes and candidate genes for possible cross-talk between the isoprenoid pathways. Genes of downstream pathways also fit well into the network. We evaluate our approach in a simulation study and using the yeast galactose network.

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