Science. 1992 Mar 27;255(5052):1718-20.

Identification of the integrin VLA-2 as a receptor for echovirus 1.

Bergelson JM, Shepley MP, Chan BM, Hemler ME, Finberg RW.

Source

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.

Abstract

Cell surface receptors for echovirus, a common human pathogen, were identified with monoclonal antibodies that protected susceptible cells from infection with echovirus 1. These monoclonal antibodies, which prevented virus attachment to specific receptor sites, recognized the alpha and beta subunits of the integrin VLA-2 (alpha 2 beta 1), a receptor for collagen and laminin. RD rhabdomyosarcoma cells expressed little VLA-2, did not bind to 35S-labeled virus, and resisted infection until transfected with complementary DNA encoding the alpha 2 subunit of VLA-2. Thus, integrins, adhesion receptors important in interactions between cells and with the extracellular matrix, can mediate virus attachment and infection.

Comment in

Science. 1992 Mar 27;255(5052):1647.

PMID:: 1553561; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. [J Clin Invest. 1993]
The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms.
Bergelson JM, Chan BM, Finberg RW, Hemler ME. J Clin Invest. 1993 Jul; 92(1):232-9.
Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2. [J Virol. 1993]
Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.
Bergelson JM, St John N, Kawaguchi S, Chan M, Stubdal H, Modlin J, Finberg RW. J Virol. 1993 Nov; 67(11):6847-52.
The I domain is essential for echovirus 1 interaction with VLA-2. [Cell Adhes Commun. 1994]
The I domain is essential for echovirus 1 interaction with VLA-2.
Bergelson JM, St John NF, Kawaguchi S, Pasqualini R, Berdichevsky F, Hemler ME, Finberg RW. Cell Adhes Commun. 1994 Oct; 2(5):455-64.
Review Multiple ligand binding functions for VLA-2 (alpha 2 beta 1) and VLA-3 (alpha 3 beta 1) in the integrin family. [Cell Differ Dev. 1990]
Review Multiple ligand binding functions for VLA-2 (alpha 2 beta 1) and VLA-3 (alpha 3 beta 1) in the integrin family.
Hemler ME, Elices MJ, Chan BM, Zetter B, Matsuura N, Takada Y. Cell Differ Dev. 1990 Dec 2; 32(3):229-38.
Review Integrin molecules involved in lymphocyte homing to Peyer's patches. [Immunol Rev. 1989]
Review Integrin molecules involved in lymphocyte homing to Peyer's patches.
Holzmann B, Weissman IL. Immunol Rev. 1989 Apr; 108:45-61.

See reviews... See all...

Cited by 64 PubMed Central articles

Interaction of decay-accelerating factor with echovirus 7. [J Virol. 2010]
Interaction of decay-accelerating factor with echovirus 7.
Plevka P, Hafenstein S, Harris KG, Cifuente JO, Zhang Y, Bowman VD, Chipman PR, Bator CM, Lin F, Medof ME, et al. J Virol. 2010 Dec; 84(24):12665-74. Epub 2010 Sep 29.
Picornaviruses. [Curr Top Microbiol Immunol. 2010]
Picornaviruses.
Tuthill TJ, Groppelli E, Hogle JM, Rowlands DJ. Curr Top Microbiol Immunol. 2010; 343:43-89.
A rapid and efficient method for studies of virus interaction at the host cell surface using enteroviruses and real-time PCR. [Virol J. 2009]
A rapid and efficient method for studies of virus interaction at the host cell surface using enteroviruses and real-time PCR.
Jonsson N, Gullberg M, Israelsson S, Lindberg AM. Virol J. 2009 Dec 7; 6:217. Epub 2009 Dec 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Identification of the integrin VLA-2 as a receptor for echovirus 1.
Identification of the integrin VLA-2 as a receptor for echovirus 1.
Science. 1992 Mar 27 ;255(5052):1718-20.

PubMed
Predisposition to renal cell carcinoma due to alteration of a cancer susceptibil...
Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.
Science. 1992 Mar 27 ;255(5052):1693-5.

PubMed
The first national reports on United States healthcare quality and disparities.
The first national reports on United States healthcare quality and disparities.
J Nurs Care Qual. 2004 Oct-Dec ;19(4):316-21.

PubMed
Active surveillance with selective delayed intervention: using natural history t...
Active surveillance with selective delayed intervention: using natural history to guide treatment in good risk prostate cancer.
J Urol. 2004 Nov ;172(5 Pt 2):S48-50; discussion S50-1.

PubMed
Prostate specific antigen doubling time as a surrogate end point for prostate ca...
Prostate specific antigen doubling time as a surrogate end point for prostate cancer specific mortality following radical prostatectomy or radiation therapy.
J Urol. 2004 Nov ;172(5 Pt 2):S42-6; discussion S46-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: