Science. 1992 Mar 27;255(5052):1693-5.

Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.

Walker C, Goldsworthy TL, Wolf DC, Everitt J.

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Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.

Abstract

A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.

PMID:: 1553556; [PubMed - indexed for MEDLINE]

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