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Neurology. 2004 Nov 9;63(9):1705-7.

Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial.

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  • 1Department of Psychiatry, University of California, San Francisco, and San Francisco VA Medical Center, CA, USA.


Participants in the Age-Related Eye Disease Study were randomly assigned to receive daily antioxidants (vitamin C, 500 mg; vitamin E, 400 IU; beta carotene, 15 mg), zinc and copper (zinc, 80 mg; cupric oxide, 2 mg), antioxidants plus zinc and copper, or placebo. A cognitive battery was administered to 2,166 elderly persons after a median of 6.9 years of treatment. Treatment groups did not differ on any of the six cognitive tests (p > 0.05 for all). These results do not support a beneficial or harmful effect of antioxidants or zinc and copper on cognition in older adults.

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