Proteins. 1992 Jan;12(1):10-23.

Functional implications of interleukin-1 beta based on the three-dimensional structure.

Veerapandian B, Gilliland GL, Raag R, Svensson AL, Masui Y, Hirai Y, Poulos TL.

Source

Center for Advanced Research in Biotechnology, University of Maryland, Rockville.

Abstract

The molecular structure of interleukin-1 beta, a hormone-like cytokine with roles in several disease processes, has been determined at 2.0 A resolution and refined to a crystallographic R-factor of 0.19. The framework of this molecule consists of 12 antiparallel beta-strands exhibiting pseudo-3-fold symmetry. Six of the strands make up a beta-barrel with polar residues concentrated at either end. Analysis of the three-dimensional structure, together with results from site-directed mutagenesis and biochemical and immunological studies, suggest that the core of the beta-barrel plays an important functional role. A large patch of charged residues on one end of the barrel is proposed as the binding surface with which IL-1 interacts with its receptor.

PMID:: 1553379; [PubMed - indexed for MEDLINE]

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Interleukin-1

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Structures reported by this article

Functional Implications Of Interleukin-1beta Based On The Three-Dimensional Structure

PDB: 4I1B

Source: Homo sapiens

Method: X-Ray Diffraction

Resolution: 2 Å

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