Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas

Fernando Gallardo; Manel Esteller; Ramon M Pujol; Carlota Costa; Teresa Estrach; Octavio Servitje

Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas

Haematologica. 2004 Nov;89(11):1401-3.

Authors

Fernando Gallardo, Manel Esteller, Ramon M Pujol, Carlota Costa, Teresa Estrach, Octavio Servitje

PMID: 15531468

Abstract

p15(INK4b), p16(INK4a) and O(6)-methylguanine DNA methyltransferase (MGMT) gene hypermethylation was studied in 22 patients with primary cutaneous T-cell lymphomas (CTCL). p15(INK4b) and p16(INK4a) inactivation is present in early and advanced disease and seems to be independent of disease stage. MGMT inactivation may play a pathogenetic role in a subset of CTCL.

Publication types

Letter

MeSH terms

Adult
Aged
Cyclin-Dependent Kinase Inhibitor p15 / genetics*
DNA Methylation
Female
Genes, p16*
Humans
Lymphoma, T-Cell, Cutaneous / genetics*
Male
Middle Aged
O(6)-Methylguanine-DNA Methyltransferase / genetics*
Promoter Regions, Genetic

Substances

Cyclin-Dependent Kinase Inhibitor p15
O(6)-Methylguanine-DNA Methyltransferase