Neurosci Biobehav Rev. 1992 Spring;16(1):107-13.

Behavioural pharmacology of 5-HT3 receptor ligands.

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Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, UK.

Abstract

Extensive studies have ascribed a role for the central 5-HT3 receptor in the modulation of behaviour. Much of the work stems from the actions of potent and selective 5-HT3 receptor antagonists; these agents reduce mesolimbic dopamine initiated hyperactivity, release suppressed behaviour, reduce the reinforcing properties and withdrawal symptoms of drugs of abuse, enhance cognitive performance and modulate appetite. This article reviews the preclinical and clinical evidence implicating the 5-HT3 receptor in these indications and discusses the potential neurochemical mechanisms underlying the behavioural changes.

PMID:: 1553101; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Receptors, Serotonin

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Cited by 4 PubMed Central articles

Evidence that the atypical 5-HT3 receptor ligand, [3H]-BRL46470, labels additional 5-HT3 binding sites compared to [3H]-granisetron. [Br J Pharmacol. 1995]
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Steward LJ, Ge J, Bentley KR, Barber PC, Hope AG, Lambert JJ, Peters JA, Blackburn TP, Barnes NM. Br J Pharmacol. 1995 Sep; 116(2):1781-8.
Nervous system distribution of the serotonin 5-HT3 receptor mRNA. [Proc Natl Acad Sci U S A. 1993]
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