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Curr Opin Cell Biol. 2004 Dec;16(6):653-62.

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration.

Author information

  • 1Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945-1400, USA. rrao@buckinstitute.org

Abstract

The accumulation of misfolded proteins (e.g. mutant or damaged proteins) triggers cellular stress responses that protect cells against the toxic buildup of such proteins. However, prolonged stress due to the buildup of these toxic proteins induces specific death pathways. Dissecting these pathways should be valuable in understanding the pathogenesis of, and ultimately in designing therapy for, neurodegenerative diseases that feature misfolded proteins.

PMID:
15530777
[PubMed - indexed for MEDLINE]
PMCID:
PMC3970707
Free PMC Article
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