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Opt Lett. 2004 Oct 1;29(19):2252-4.

Polarization-resolved second-harmonic-generation optical coherence tomography in collagen.

Author information

  • 1Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA. brian.applegate@duke.edu

Abstract

We describe a novel imaging technique, second-harmonic-generation optical coherence tomography (SHOCT). This technique combines the spatial resolution and depth penetration of optical coherence tomography (OCT) with the molecular sensitivity of second-harmonic-generation spectroscopy. As a consequence of the coherent detection required for OCT, polarization-resolved images arise naturally. We demonstrate this new technique on a skin sample from the belly of Icelandic salmon, acquiring polarization-resolved SHOCT and OCT images simultaneously.

PMID:
15524371
[PubMed - indexed for MEDLINE]
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