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Nat Struct Mol Biol. 2004 Nov;11(11):1049-53.

SRP meets the ribosome.

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  • 1Biochemie-Zentrum der Universit├Ąt Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.


Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.

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