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Nat Struct Mol Biol. 2004 Nov;11(11):1037-43.

Regulated nucleosome mobility and the histone code.

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  • 1Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, Maryland 21205, USA.


Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.

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