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Trends Genet. 2004 Dec;20(12):598-603.

Wide genome comparisons reveal the origins of the human X chromosome.

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  • 1Department of Human Genetics, University of Ulm, D-89070 Ulm, Germany.


The eutherian X chromosome has one of the most conserved gene arrangements in mammals. Although earlier comparisons with distantly related mammalian groups pointed towards separate origins for the short and long arms, much deeper comparisons are now possible using draft sequences of the chicken genome, in combination with genome sequences from pufferfish and zebrafish. This enables surprising new insights into the origins of the mammalian X chromosome.

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