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Dermatol Surg. 2004 Nov;30(11):1424-9.

Management of squamous cell carcinoma in a patient with recessive-type epidermolysis bullosa dystrophica.

Author information

  • 1Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Abstract

BACKGROUND:

Surgical treatment of a recessive dystrophic epidermolysis bullosa patient is very difficult for both the surgeon and the anesthetist because of the fragility of the skin and abnormal nature of the tumor bed.

OBJECTIVE:

We report a case of 54-year-old Japanese recessive dystrophic epidermolysis bullosa patient with squamous cell carcinoma (SCC) of the lateral malleolus.

METHODS:

A tumor measuring 5.0 x 5.5 cm was surgically excised. The defect was then reconstructed by full-thickness skin grafting. To avoid airway complications, general anesthesia was administered using a face mask. Because the regional lymph nodes were swollen before surgery, the patient underwent sentinel lymph node biopsy.

RESULTS:

The patient remains well with no sign of recurrence or metastasis 7 months after surgery.

CONCLUSION:

To preserve activities of daily living, surgery should be performed for squamous cell carcinomas arising in recessive dystrophic epidermolysis bullosa patients.

PMID:
15522026
[PubMed - indexed for MEDLINE]
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