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1: Nat Rev Mol Cell Biol. 2004 Nov;5(11):937-44.Click here to read Links

Happy Hollidays: 40th anniversary of the Holliday junction.

Liu Y, West SC.

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

In 1964, the geneticist Robin Holliday proposed a mechanism of DNA-strand exchange that attempted to explain gene-conversion events that occur during meiosis in fungi. His proposal marked the birthday of the now famous cross-stranded DNA structure, or Holliday junction. To understand the importance of the Holliday model we must look back in the history of science beyond the last 40 years, to a time when theories of heredity were being proposed by Gregor Johann Mendel.

PMID: 15520813 [PubMed - indexed for MEDLINE]