Nat Rev Mol Cell Biol. 2004 Nov;5(11):875-85.

The RAF proteins take centre stage.

Source

Signal Transduction Team, Cancer Research UK Centre of Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

Abstract

Since their discovery over 20 years ago, the RAF proteins have been intensely studied. For most of that time, the focus of the field has been the C-RAF isoform and its role as an effector of the RAS proteins. However, a report that implicates B-RAF in human cancer has highlighted the importance of all members of this protein kinase family and recent studies have uncovered intriguing new data relating to their complex regulation and biological functions.

PMID:: 15520807; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Raf: a strategic target for therapeutic development against cancer. [J Clin Oncol. 2005]
Review Raf: a strategic target for therapeutic development against cancer.
Beeram M, Patnaik A, Rowinsky EK. J Clin Oncol. 2005 Sep 20; 23(27):6771-90.
Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates. [J Biol Chem. 2007]
Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates.
Baljuls A, Mueller T, Drexler HC, Hekman M, Rapp UR. J Biol Chem. 2007 Sep 7; 282(36):26575-90. Epub 2007 Jul 5.
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. [J Biol Chem. 2005]
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
Trakul N, Menard RE, Schade GR, Qian Z, Rosner MR. J Biol Chem. 2005 Jul 1; 280(26):24931-40. Epub 2005 May 10.
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. [Genomics. 2003]
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.
Yuryev A, Wennogle LP. Genomics. 2003 Feb; 81(2):112-25.
Review Second nature: biological functions of the Raf-1 "kinase". [FEBS Lett. 2005]
Review Second nature: biological functions of the Raf-1 "kinase".
Baccarini M. FEBS Lett. 2005 Jun 13; 579(15):3271-7. Epub 2005 Mar 23.

See reviews... See all...

Cited by over 100 PubMed Central articles

Absence of BRAF exon 15 mutations in multiple myeloma and Waldenström's macroglobulinemia questions its validity as a therapeutic target in plasma cell neoplasias. [Am J Blood Res. 2013]
Absence of BRAF exon 15 mutations in multiple myeloma and Waldenström's macroglobulinemia questions its validity as a therapeutic target in plasma cell neoplasias.
Hatzimichael E, Murray S, Briasoulis E. Am J Blood Res. 2013; 3(2):181-5. Epub 2013 May 5.
Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. [Nat Commun. 2013]
Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region.
Liu X, Xiong C, Jia S, Zhang Y, Chen YG, Wang Q, Meng A. Nat Commun. 2013 Apr 16; 4:1728.
Advances in personalized targeted treatment of metastatic melanoma and non-invasive tumor monitoring. [Front Oncol. 2013]
Advances in personalized targeted treatment of metastatic melanoma and non-invasive tumor monitoring.
Klinac D, Gray ES, Millward M, Ziman M. Front Oncol. 2013; 3:54. Epub 2013 Mar 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
MedGen (Bookshelf cited)
Related records in MedGen based on citations in GeneReviews and Medical Genetics Summaries
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

The RAF proteins take centre stage.
The RAF proteins take centre stage.
Nat Rev Mol Cell Biol. 2004 Nov ;5(11):875-85.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The RAF proteins take centre stage.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information