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Trends Cell Biol. 2004 Nov;14(11):594-7.

An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA.

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  • 1Department of Biochemistry and Biophysics, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 712, University of Rochester, Rochester, NY 14642, USA.


Quality-control mechanisms function in cells to ensure proper gene expression. Nonsense-mediated mRNA decay (NMD) is one such mechanism and it degrades abnormal mRNAs that contain a premature-termination codon. Although NMD is conserved in all eukaryotes that have been examined, it can manifest mechanistic differences in different organisms. A recent study using Drosophila melanogaster describes a new mechanistic twist to NMD.

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