Growth Factors. 2004 Sep;22(3):141-50.

Wnt signaling: physiology and pathology.

Source

Department of Cell Biology, NC1, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

Abstract

Signaling by the Wnt family of secreted glycoproteins has been demonstrated to be essential both in normal embryonic development and in the pathogenesis of a variety of diseases, including cancer. This signaling pathway is exquisitely regulated by a large and complex array of proteins, which act as agonists or antagonists of signal transduction, modulating the Wnt signal extracellularly, in the cytoplasm and in the nucleus. Here, we will briefly review the canonical Wnt signaling pathway and consider molecular defects in Wnt signaling components known to promote uncontrolled cell growth following induction of Wnt signaling. We will also focus on two recently identified factors in this pathway, that seem to act as Wnt signaling antagonists, one functioning in the cytoplasm called Disabled-2 and the other in the nucleus named Chibby.

PMID:: 15518237; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review The Wnt connection to tumorigenesis. [Int J Dev Biol. 2004]
Review The Wnt connection to tumorigenesis.
Behrens J, Lustig B. Int J Dev Biol. 2004; 48(5-6):477-87.
Review Wnt signaling through canonical and non-canonical pathways: recent progress. [Growth Factors. 2005]
Review Wnt signaling through canonical and non-canonical pathways: recent progress.
Widelitz R. Growth Factors. 2005 Jun; 23(2):111-6.
Review Wnt/beta-catenin signaling pathway as a novel cancer drug target. [Curr Cancer Drug Targets. 2004]
Review Wnt/beta-catenin signaling pathway as a novel cancer drug target.
Luu HH, Zhang R, Haydon RC, Rayburn E, Kang Q, Si W, Park JK, Wang H, Peng Y, Jiang W, et al. Curr Cancer Drug Targets. 2004 Dec; 4(8):653-71.
Review The promise and perils of Wnt signaling through beta-catenin. [Science. 2002]
Review The promise and perils of Wnt signaling through beta-catenin.
Moon RT, Bowerman B, Boutros M, Perrimon N. Science. 2002 May 31; 296(5573):1644-6.
Review Secreted WNT antagonists as tumor suppressors: pro and con. [Front Biosci. 2006]
Review Secreted WNT antagonists as tumor suppressors: pro and con.
Rubin JS, Barshishat-Kupper M, Feroze-Merzoug F, Xi ZF. Front Biosci. 2006 Sep 1; 11:2093-105. Epub 2006 Sep 1.

See reviews... See all...

Cited by 11 PubMed Central articles

Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. [Diabetes. 2011]
Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.
Palmer ND, Hester JM, An SS, Adeyemo A, Rotimi C, Langefeld CD, Freedman BI, Ng MC, Bowden DW. Diabetes. 2011 Feb; 60(2):662-8. Epub 2010 Oct 27.
Review Molecular mechanisms of receptor-mediated endocytosis in the renal proximal tubular epithelium. [J Biomed Biotechnol. 2010]
Review Molecular mechanisms of receptor-mediated endocytosis in the renal proximal tubular epithelium.
Saito A, Sato H, Iino N, Takeda T. J Biomed Biotechnol. 2010; 2010:403272.
Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. [Am J Pathol. 2009]
Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models.
Chen Y, Hu Y, Zhou T, Zhou KK, Mott R, Wu M, Boulton M, Lyons TJ, Gao G, Ma JX. Am J Pathol. 2009 Dec; 175(6):2676-85. Epub 2009 Nov 5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Wnt signaling: physiology and pathology.
Wnt signaling: physiology and pathology.
Growth Factors. 2004 Sep ;22(3):141-50.

PubMed
Dihydrotestosterone is a peripheral paracrine hormone.
Dihydrotestosterone is a peripheral paracrine hormone.
J Androl. 1992 Jan-Feb ;13(1):23-7.

PubMed
Ultra-fast high-resolution agarose electrophoresis of DNA and RNA using low-mola...
Ultra-fast high-resolution agarose electrophoresis of DNA and RNA using low-molarity conductive media.
Biotechniques. 2004 Oct ;37(4):598, 600, 602.

PubMed
Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to...
Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to IL-23/IL-18 gene transfer in a rat osteosarcoma model.
Anticancer Res. 2004 Sep-Oct ;24(5A):2861-7.

PubMed
The utility of intramuscular ziprasidone in the management of acute psychotic ag...
The utility of intramuscular ziprasidone in the management of acute psychotic agitation.
Ann Clin Psychiatry. 2004 Jul-Sep ;16(3):145-54.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: