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Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism.
del Rincón SV, Guo Q, Morelli C, Shiu HY, Surmacz E, Miller WH.
Oncogene. 2004 Dec 9;23(57):9269-79.
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Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells.
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